Bryan Johnson's Blueprint Protocol: The Australian Version (2025)

ProtocolHub provides educational information only. All peptide and pharmaceutical therapies require consultation with an AHPRA-registered medical practitioner. This does not constitute medical advice. ProtocolHub may earn affiliate commissions from partner referrals — this does not affect our editorial recommendations.

This protocol is based on Bryan Johnson's publicly documented Blueprint protocol at protocol.bryanjohnson.com and his "Don't Die" Netflix documentary (2025). Johnson has not endorsed ProtocolHub or reviewed this content. Protocols are adapted for the Australian regulatory environment and may differ from his personal approach.

Bryan Johnson's Blueprint protocol costs $2 million a year when you include his private medical team, quarterly blood work, DEXA scans, and the full compound list. The Australian accessible version — covering NMN, GHK-Cu, Epithalon, collagen, and the foundational supplement layer — runs around $350–$600 AUD per month depending on how far you take the prescription layer. Here's every compound, what it costs at an Australian pharmacy or compounding clinic, whether you need a prescription, and what to skip entirely.

What does Bryan Johnson's Blueprint protocol actually include?

Johnson's publicly documented routine — updated regularly at protocol.bryanjohnson.com — is one of the most detailed and transparent self-experimentation records in existence. The core daily compounds as of early 2025:

Foundation layer (daily): NMN or NR for NAD+ restoration, Vitamin C, Vitamin D3 + K2, Omega-3 EPA/DHA, Magnesium L-Threonate, Collagen Peptides, Lutein, Zeaxanthin, and a comprehensive blood panel-matched micronutrient stack.

Peptide layer: GHK-Cu (copper peptide) topically in his Blueprint serum; some evidence suggests he uses injectable forms for systemic effects. Epithalon in annual cycles for telomerase activation.

Prescription layer: Metformin (for blood glucose management), Acarbose (post-meal glucose control), and Rapamycin (cycled, for mTOR inhibition). These are the most difficult to access in Australia.

Body composition: Ca-AKG (Calcium Alpha-Ketoglutarate) — one of the ingredients Johnson credits with meaningful biological age changes in animal studies.

The Australian version — compound by compound

What you can start today without a prescription

NMN — $50–$80 AUD/month

NMN is TGA-approved and requires no prescription in Australia. Johnson's documented dose is 500 mg/day (he has also used NR, the alternative NAD+ precursor at 450 mg/day). Start at 500 mg/day and increase to 1,000 mg/day after two weeks. Available at iHerb Australia, Chemist Warehouse, and specialist supplement retailers. Look for third-party tested products with minimum 98% purity.

Collagen Peptides + Vitamin C — $35–$70 AUD/month combined

Johnson consumes 20–30 g of collagen peptides daily paired with 500 mg Vitamin C — which is a required cofactor for collagen synthesis. Available at every Australian health food retailer and major pharmacy. Hydrolysed bovine collagen is the standard form.

Ca-AKG (Calcium Alpha-Ketoglutarate) — $40–$70 AUD/month

Animal studies (published in Cell Metabolism, 2020) showed up to 12% lifespan extension and healthspan improvements in mice. Human data is limited but emerging. Available through Australian compounding pharmacies without prescription, and increasingly through specialist longevity supplement retailers online. Johnson includes it in his Blueprint Longevity Mix.

Vitamin D3 + K2, Omega-3, Magnesium — $40–$80 AUD/month combined

All OTC in Australia. Johnson's approach: D3 5,000 IU daily paired with 100 mcg MK-7 K2 (to direct calcium to bones rather than arteries). Omega-3 at 2–3 g EPA/DHA combined. Magnesium L-Threonate for the brain-penetrating form. Standard products at any Australian pharmacy.

OTC layer total: $165–$300 AUD/month

What requires a prescription in Australia

GHK-Cu injectable — $120–$200 AUD/month

GHK-Cu is a naturally occurring copper tripeptide that declines significantly with age. Johnson uses it topically in his Blueprint peptide serum. Injectable GHK-Cu achieves systemic tissue remodelling effects that topical application cannot reach — promoting collagen synthesis, wound healing, and antioxidant enzyme expression.

In Australia, injectable GHK-Cu is classified as compounding-only and requires a prescription from an AHPRA-registered practitioner, dispensed through a licensed compounding pharmacy. Topical formulations may be accessed through some skincare compounders without prescription.

Epithalon — $150–$280 AUD per annual course

Epithalon is a synthetic tetrapeptide that directly activates telomerase — the enzyme that repairs telomeres. Johnson's publicly documented cycle: 5–10 mg/day for 10–20 days, 1–2 times per year. Not taken daily year-round.

In Australia, Epithalon is classified as Schedule 4 research-use and requires a prescription from an AHPRA-registered practitioner. Accessed via telehealth consultation + licensed compounding pharmacy. The annual course structure makes the cost per month low when amortised.

Compare Australian clinics that can prescribe this protocol →

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Metformin — $15–$40 AUD/month if prescribed

Metformin is Schedule 4 in Australia and typically prescribed for Type 2 diabetes. Johnson takes it for blood glucose management and longevity purposes. In Australia, off-label prescribing for longevity purposes is legal but requires a clinical assessment — most AHPRA-registered GPs will require fasting glucose and HbA1c results before considering it. A longevity-focused telehealth clinic is the practical pathway.

Important caveat: several longevity researchers, including Peter Attia, have raised concerns about metformin potentially blunting training adaptations in individuals who exercise regularly. Discuss this specifically with your prescriber.

Acarbose — $15–$40 AUD/month if prescribed

Acarbose is Schedule 4 and slows carbohydrate absorption post-meal, flattening glucose spikes. Johnson uses it specifically after meals containing starch. Same prescribing pathway as Metformin: requires clinical assessment.

What about Rapamycin?

Johnson takes Rapamycin in weekly cycles for mTOR inhibition. In Australia, Rapamycin (sirolimus) is Schedule 4 and primarily used as an immunosuppressant in transplant medicine. Off-label longevity prescribing exists but is limited to specialist physicians — most telehealth GPs will not prescribe it for longevity purposes. This guide does not include it in the accessible Australian version. If this is a priority, consult a specialist longevity physician directly.

How much does the Australian Blueprint protocol cost?

Compound	Monthly cost (AUD)	Prescription?
NMN 500–1,000 mg/day	$50–$80	No
Collagen + Vitamin C	$35–$70	No
Ca-AKG 1 g/day	$40–$70	No
Vitamin D3/K2 + Omega-3 + Magnesium	$40–$80	No
OTC total	$165–$300	—
GHK-Cu injectable	$120–$200	Yes
Epithalon (amortised monthly)	$25–$47	Yes
Metformin (if prescribed)	$15–$40	Yes
Acarbose (if prescribed)	$15–$40	Yes
Full stack total	$340–$627	—

How do you find a prescriber for the prescription layer?

A longevity-focused telehealth clinic is the most efficient pathway. The key requirement is a prescriber who includes baseline blood work — at minimum: IGF-1, fasting glucose, HbA1c, lipid panel, CRP, testosterone (free and total), and SHBG. The prescription layer should only be introduced after reviewing these markers.

Thrive Rx and similar longevity-focused telehealth clinics include a comprehensive blood panel as part of their intake — which aligns with the biomarker-first philosophy Johnson documents in his own protocol.

ProtocolHub provides educational information only. All peptide and pharmaceutical therapies require consultation with an AHPRA-registered medical practitioner. This does not constitute medical advice.

Bryan Johnson's Blueprint Protocol: The Australian Version ($400/Month, Not $2 Million)