Peptide profile

Semaglutide

Ozempic / Wegovy / GLP-1 agonist

Fat Loss

The most clinically proven GLP-1 medication for weight management and metabolic health.

Evidence Level

Anecdotal
Emerging
Moderate
Strong

Legal Status

TGA Approved

Dosage

0.25 mg/week (titrate to 2.4 mg/week over 16 weeks)

Route

subcutaneous injection

How it works

Mimics the GLP-1 hormone, slowing gastric emptying, suppressing appetite centrally, and improving insulin sensitivity. Reduces caloric intake by an average of 30–39% in clinical trials.

Research summary

TGA-approved (Wegovy) for chronic weight management in Australia since 2024. The STEP 1 trial showed average 14.9% body weight loss over 68 weeks. Currently not PBS-listed for obesity — patients pay full cost. Ozempic (lower dose, diabetes indication) is PBS-listed for eligible Type 2 diabetes patients only.

Cycle duration

Ongoing (long-term management)

Stacks well with

These peptides complement Semaglutide's mechanism and are commonly combined in protocols.

Fat Loss
Moderate

AOD-9604

Developed at Monash University, Melbourne — Australia's own fat-burning peptide with no blood sugar or muscle effects.

300 mcg/day subcutaneous, taken fasted in the morningView

Supplements that pair with Semaglutide

These supplements directly amplify or support Semaglutide's mechanism of action.

CoreModerate

Berberine

A plant-derived metabolic activator — improves insulin sensitivity and supports fat loss via the same pathway as metformin.

500mg, 2–3 times daily with mealsView

Protocols using this peptide

Fat Lossbeginner

GLP-1 Fat Loss Protocol

The clinically proven pathway for sustainable weight loss — combining GLP-1 therapy, targeted supplements, and a nutrition framework designed for Australian patients.

Strong evidenceTGA-approved compound

16.9% avg body weight loss over 68 weeks in the STEP 1 trial (Semaglutide 2.4 mg vs placebo). FDA & TGA approved.

Semaglutide
1 stepOngoing (minimum 3 months)
$199–$299 AUD / monthView
Fat Lossintermediate

Advanced Fat Loss Stack

Combining GLP-1 appetite suppression with targeted fat metabolism support.

Moderate evidenceTGA-approved compound

AOD-9604 showed 2.6 kg more fat loss vs placebo over 12 weeks in clinical trials, with no effect on blood glucose.

SemaglutideAOD-9604
2 steps12 weeks
$280–$420 AUD / monthView

Free tool

Protein targets for your Semaglutide

Protein requirements vary significantly by protocol goal and activity level.

80kg

160g

Daily total

53g

Per meal (3 meals)

2.0g/kg

Per kg bodyweight

Top sources to hit 160g daily

Chicken breast (cooked)~520g hits target
Whey protein (1 scoop ~30g)~200g hits target
Salmon fillet (cooked)~640g hits target
Eggs~23 eggs hits target
Greek yoghurt (200g serve)~8 serves hits target
Lean beef mince (cooked)~620g hits target

How this connects to your protocol

On GLP-1 protocols, hitting protein targets is your most critical nutritional variable. Semaglutide suppresses appetite — the risk is eating too little protein and losing muscle alongside fat. This number protects your lean mass.

Build my complete protocol →Open full calculator

Targets are evidence-based estimates. Consult your practitioner for personalised advice.

Risks & side effects

Nausea, vomiting, diarrhoea (especially during titration)
Potential pancreatitis risk
Gallbladder disease
Weight regain on cessation — ~two-thirds regained within 1 year of stopping
Currently not PBS-listed for weight loss in Australia — full out-of-pocket cost

How to access in Australia

This medication is TGA-approved and available with a prescription from any Australian GP or specialist. Contact a telehealth clinic below for convenient access.

Find a prescriber

Australian clinics that prescribe Semaglutide or treat related goals.

Rx

Thrive Rx

Telehealth Clinic
4.8(312)

Australia's most thorough longevity and peptide clinic — blood panel first, protocol second.

$199–$599 AUD / month Australia-wide
AHPRA-registered clinicians
Comprehensive blood panel included in membership
Ongoing biomarker tracking every 6 months
Higher price point than GLP-1 only clinics
Requires full health assessment before any prescription
Visit clinic

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PX

Phyx

Telehealth Clinic
4.7(260)

The Home of Longevity — performance-focused peptide therapy, supplements, and Afterpay-supported plans across Australia.

$150–$500 AUD / month Australia-wide
One of the widest peptide menus in Australia — 19+ compounds available
Afterpay available — pay in 4 easy instalments
Includes hard-to-find peptides: Epitalon, MOTS-C, Oxytocin, DHEA
Newer brand — less established review base than Thrive Rx or Pilot
Premium pricing on some specialised compounds

Peptides available (19)

AOD 9604CJC 1295IpamorelinHCGMOTS-CBPC 157CJC 1295 + IpamorelinTB-500+11 more
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J

Juniper

Telehealth Clinic
4.6(4,821)

Australia's largest women's GLP-1 weight loss program — 100,000+ patients.

Weight loss only
$129–$299 AUD / month Australia-wide
Largest patient base in Australia — 100,000+ women
Integrated app with health coaching and nutrition plan
LegitScript certified for safety and compliance
Women only — men should see Pilot (sister platform) instead
GLP-1 weight loss focus only — not a full peptide clinic
Visit clinic

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Medical disclaimer

The information on this page is for educational purposes only and does not constitute medical advice. All peptide and supplement therapies should be discussed with an AHPRA-registered medical practitioner before use. ProtocolHub does not prescribe, dispense, or supply any therapeutic goods. Always consult a qualified healthcare professional before starting any new health protocol.

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