Peptide profile
Semax
ACTH 4-7 Pro-Gly-Pro / Semakс / The BDNF Peptide
The most potent BDNF-upregulating peptide — acute cognitive enhancement, neuroprotection, and stroke recovery support.
Evidence Level
Legal Status
Dosage
Route
How it works
A synthetic analogue of the ACTH 4-10 fragment with an appended Pro-Gly-Pro sequence that dramatically extends its half-life. Semax directly activates BDNF receptors (TrkB) and NGF (nerve growth factor) pathways, promoting neuroplasticity and synaptogenesis. It increases dopaminergic and serotonergic activity in the hippocampus and modulates the enkephalinase system. Its neuroprotective effects are among the most well-documented of any peptide — it has demonstrated efficacy in stroke recovery, optic nerve disease, and cognitive decline in multiple controlled human trials.
Research summary
Developed at the Institute of Molecular Genetics, Russian Academy of Sciences, and approved in Russia for treatment of stroke, optic nerve disease, and peptic ulcers. Over 60 published studies including multiple randomised controlled trials in stroke recovery and cognitive impairment. Human data confirms BDNF and NGF upregulation within 24 hours of administration. Phase II trials demonstrated significant cognitive improvement in patients with memory disorders. The most extensively human-tested cognitive peptide available.
Cycle duration
2–4 weeks on, 2 weeks off
Stacks well with
These peptides complement Semax's mechanism and are commonly combined in protocols.
Selank
Russia's most studied anxiolytic peptide — reduces anxiety and enhances cognitive function without sedation or dependency.
BPC-157
The most researched healing peptide — gut repair, tendon recovery, and injury healing.
Ipamorelin + CJC-1295
The gold standard GH-releasing combination for anti-ageing, body recomposition, and sleep quality.
NMN
The NAD+ precursor taken daily by both Andrew Huberman and Bryan Johnson — restores cellular energy production that declines with age.
Cerebrolysin
A clinically approved neuropeptide mixture derived from porcine brain proteins — with 30+ years of clinical use in Europe and Asia for stroke recovery, Alzheimer's, and cognitive enhancement.
Supplements that pair with Semax
These supplements directly amplify or support Semax's mechanism of action.
Lion's Mane
The only supplement clinically confirmed to stimulate NGF synthesis — directly promoting neurogenesis and cognitive resilience.
Bacopa Monnieri
Ayurvedic adaptogen with the strongest clinical evidence for memory consolidation and anxiety reduction of any herbal nootropic.
Protocols using this peptide
Free tool
Protein targets for your Semax
Protein requirements vary significantly by protocol goal and activity level.
144g
Daily total
48g
Per meal (3 meals)
1.8g/kg
Per kg bodyweight
Top sources to hit 144g daily
How this connects to your protocol
Amino acids are precursors to neurotransmitters including dopamine, serotonin, and acetylcholine. Adequate protein supports the cognitive benefits of your nootropic protocol.
Targets are evidence-based estimates. Consult your practitioner for personalised advice.
Risks & side effects
How to access in Australia
Check with an AHPRA-registered practitioner for the current legal pathway to access this compound in Australia.
Find a prescriber
Australian clinics that prescribe Semax or treat related goals.
Thrive Rx
Telehealth ClinicAustralia's most thorough longevity and peptide clinic — blood panel first, protocol second.
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Research supplier information
Semax is available from Australian research suppliers below. These are not prescription services — they sell research-use-only compounds without medical supervision. ProtocolHub recommends the prescription pathway through a verified clinic. This information is provided so you have complete access to the Australian market.
Medical disclaimer
The information on this page is for educational purposes only and does not constitute medical advice. All peptide and supplement therapies should be discussed with an AHPRA-registered medical practitioner before use. ProtocolHub does not prescribe, dispense, or supply any therapeutic goods. Always consult a qualified healthcare professional before starting any new health protocol.
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