Supplement profile
Lion's Mane
The only supplement clinically confirmed to stimulate NGF synthesis — directly promoting neurogenesis and cognitive resilience.
Evidence Level
Dosage
Timing
Form
How it works
Hericium erinaceus contains two unique classes of bioactive compounds: hericenones (in the fruiting body) and erinacines (in the mycelium). Both directly stimulate the synthesis and secretion of Nerve Growth Factor (NGF) — the protein responsible for the growth, maintenance, and survival of neurons. Unlike most nootropics that modulate existing neurotransmitter systems, Lion's Mane operates at a more foundational level by supporting the structural integrity and growth of neural tissue itself. Erinacines have also demonstrated the ability to cross the blood-brain barrier directly.
What to look for
Look for dual-extracted products that process both the fruiting body (hericenones) and mycelium (erinacines) — either component alone delivers partial benefit. Standardised to minimum 25–30% beta-glucan content. Avoid mycelium-on-grain products where the substrate (oats or rice) constitutes the majority of the product — this dilutes active compound density significantly. Australian brands: check for third-party testing certificates.
Our recommendation
Buying Lion's Mane
No brand partner yet. Here's our independent guidance on what makes a quality product.
Look for third-party tested products with verified purity, correct form and dosage. Avoid proprietary blends and underdosed formulations.
When ProtocolHub establishes a verified partner for this supplement, a specific product recommendation will appear here. Our editorial recommendations are never influenced by commercial relationships.
Are you a supplier? Contact us to get listedPairs with these peptides
Lion's Mane directly amplifies the effects of these peptide protocols.
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The gold standard GH-releasing combination for anti-ageing, body recomposition, and sleep quality.
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Protocols using Lion's Mane
These clinician-reviewed protocol stacks include Lion's Mane as part of their supplement plan.
The Neuroscience Performance Protocol
Inspired by Andrew Huberman's publicly documented research — optimise testosterone, cognition, sleep, and GH axis.
NMN elevated NAD+ levels by 38% in human trials over 60 days. Huberman's stack is one of the most research-cited protocols publicly documented.
Inspired by
Andrew Huberman, PhD
Stanford Neuroscientist & Host, Huberman Lab Podcast
Longevity & Anti-Ageing Stack
The core protocol for GH optimisation, cellular repair, and healthy ageing.
GHK-Cu increased collagen by 70% in skin studies. Ipamorelin restores youthful GH pulsatility without cortisol elevation.
The Blueprint Longevity Protocol
Inspired by Bryan Johnson's Project Blueprint — Australia's most comprehensive biological age reversal stack.
Bryan Johnson spent $2M+/yr on longevity testing. This protocol adapts his publicly documented peptide and supplement regimen for Australian access.
Inspired by
Bryan Johnson
Founder, Project Blueprint | Don't Die (Netflix, 2025)
The Outlive Longevity Protocol
Inspired by Dr. Peter Attia's physician-grade framework — the most evidence-conservative longevity protocol available in Australia.
Peter Attia's framework targets the "four horsemen" — this protocol implements his publicly shared peptide and rapamycin-adjacent strategies.
Inspired by
Peter Attia, MD
Longevity Physician | Host, The Drive Podcast | Author, Outlive
See your complete supplement stack
Get Lion's Mane plus every supplement matched to your specific protocol goal — with peptides, training, and nutrition all included.
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Medical disclaimer
The information on this page is for educational purposes only and does not constitute medical advice. All peptide and supplement therapies should be discussed with an AHPRA-registered medical practitioner before use. ProtocolHub does not prescribe, dispense, or supply any therapeutic goods. Always consult a qualified healthcare professional before starting any new health protocol.