Protocol stack
Advanced Muscle Building Stack
For experienced peptide users who have completed at least one cycle of the beginner stack and have confirmed IGF-1 and metabolic blood work with their prescriber. Adding IGF-1 LR3 to the GH secretagogue base creates a two-axis anabolic effect: GH drives fat loss and systemic recovery while IGF-1 LR3 acts directly on muscle cells to drive hypertrophy and hyperplasia. BPC-157 is included as connective tissue insurance — aggressive training with elevated GH and IGF-1 can outpace tendon and ligament adaptation.
What's in this stack
Ipamorelin + CJC-1295
200–300 mcg of each peptide · Once nightly, 5 nights on / 2 nights off
Timing: 30 minutes before bed, fasted
The GH foundation of the stack. Do not increase above 300 mcg — at this level you are stimulating near-maximal pituitary output. More is not more with secretagogues.
IGF-1 LR3
20–40 mcg · Daily on training days only (4–5 days per week)
Timing: Immediately post-workout — within 15 minutes of finishing training
Always inject post-workout with a fast-acting carbohydrate available (e.g. banana, rice cakes). IGF-1 LR3 can cause hypoglycaemia — never inject fasted or pre-workout. Cycle strictly: 4–6 weeks on, minimum 4 weeks off to prevent receptor desensitisation. Use sites close to the muscle group trained that day for localised uptake.
BPC-157
250 mcg · Once daily
Timing: Morning, fasted
Connective tissue protection throughout the cycle. Non-negotiable at this training intensity. If a specific injury develops, increase to 500 mcg and inject near the injury site. Continue BPC-157 for 2 weeks after the IGF-1 LR3 cycle ends.
Step-by-step guide
Ipamorelin + CJC-1295 — 200–300 mcg of each peptide Once nightly, 5 nights on / 2 nights off
30 minutes before bed, fasted
The GH foundation of the stack. Do not increase above 300 mcg — at this level you are stimulating near-maximal pituitary output. More is not more with secretagogues.
IGF-1 LR3 — 20–40 mcg Daily on training days only (4–5 days per week)
Immediately post-workout — within 15 minutes of finishing training
Always inject post-workout with a fast-acting carbohydrate available (e.g. banana, rice cakes). IGF-1 LR3 can cause hypoglycaemia — never inject fasted or pre-workout. Cycle strictly: 4–6 weeks on, minimum 4 weeks off to prevent receptor desensitisation. Use sites close to the muscle group trained that day for localised uptake.
BPC-157 — 250 mcg Once daily
Morning, fasted
Connective tissue protection throughout the cycle. Non-negotiable at this training intensity. If a specific injury develops, increase to 500 mcg and inject near the injury site. Continue BPC-157 for 2 weeks after the IGF-1 LR3 cycle ends.
Free tool
Your protocol timeline
See your titration schedule, expected results, and blood work dates mapped to real calendar dates.
Protocol starts
16 Apr 2026Begin Ipamorelin/CJC-1295 nightly. Start MK-677 at 10mg. Establish protein target and training baseline.
Week 0 · StartAdaptation phase
23 Apr 2026MK-677 appetite increase is significant — plan your meals. Sleep quality often improves within the first week.
Week 1 · MilestoneMK-677 increase
7 May 2026Increase MK-677 to 15–20mg if 10mg is well tolerated. Water retention from this point is normal and temporary.
Week 3 · Dose changeIGF-1 blood test
14 May 2026Test IGF-1 and fasting glucose to confirm protocol is working and to guide any dose adjustments.
Week 4 · Blood workStrength gains visible
28 May 2026Progressive overload should be clearly measurable by now. Training volume can increase safely.
Week 6 · Expected resultConsider IGF-1 LR3
11 June 2026For advanced users: if blood work supports it and you have prescriber approval, IGF-1 LR3 can be added post-workout on training days.
Week 8 · Dose changeFirst cycle complete
9 July 2026Assess progress — measure body composition, strength benchmarks, and sleep quality. Continue or cycle off as prescribed.
Week 12 · MilestoneCycle review
6 Aug 2026Schedule review with your clinic. Retest IGF-1, fasting glucose, and testosterone to assess hormonal response.
Week 16 · Blood workTimelines are general estimates. Your prescribing practitioner will personalise your schedule.
Supplements for this protocol
Core supplements that directly support your Advanced Muscle Building Stack.
Creatine Monohydrate
The most evidence-backed performance supplement in existence — increases strength, power, and muscle recovery.
Whey Protein
The most bioavailable protein source — essential for hitting protein targets that support muscle growth and recovery.
Magnesium Glycinate
The most bioavailable form of magnesium — essential for sleep quality, muscle recovery, and hormone production.
Vitamin D3 + K2
The foundational hormone stack — critical for testosterone production, immune function, bone density, and GH receptor sensitivity.
Prescription required
All protocols listed on ProtocolHub require a prescription from an Australian AHPRA-registered medical practitioner. Do not attempt to self-prescribe or source peptides without medical supervision.
Get this protocol prescribed
Thrive Rx
Telehealth ClinicAustralia's most thorough longevity and peptide clinic — blood panel first, protocol second.
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Phyx
Telehealth ClinicThe Home of Longevity — performance-focused peptide therapy, supplements, and Afterpay-supported plans across Australia.
Peptides available (19)
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