Peptide profile

Noopept

N-phenylacetyl-L-prolylglycine ethyl ester / GVS-111 / The Russian Smart Drug

Cognitive

A synthetic dipeptide 1,000 times more potent than piracetam — rapid cognitive enhancement, memory consolidation, and neuroprotection.

Evidence Level

Anecdotal
Emerging
Moderate
Strong

Legal Status

Research Use Only

Dosage

10–30 mg per day

Route

sublingual, oral capsule

How it works

A synthetic dipeptide that is metabolised in the body to cycloprolylglycine — an endogenous neuropeptide. Noopept modulates AMPA-type glutamate receptors (enhancing fast synaptic transmission), increases BDNF and NGF expression in the hippocampus, and reduces glutamate-induced excitotoxicity. It demonstrates anxiolytic and neuroprotective properties alongside its nootropic effects. Unlike racetam compounds, it crosses the blood-brain barrier extremely efficiently and is active at doses approximately 1,000 times lower than piracetam.

Research summary

Developed at the Zakusov Institute of Pharmacology in Russia in the 1990s. Multiple published studies in cognitive impairment models and mild cognitive disorder in humans. A 2014 trial demonstrated significant improvement in cognitive function in patients with mild cognitive impairment. NGF and BDNF upregulation confirmed in hippocampal tissue studies. Widely used in Russian clinical practice for cognitive enhancement and neurological recovery. The most commonly used nootropic peptide globally.

Cycle duration

1.5–3 months on, 1 month off

Stacks well with

These peptides complement Noopept's mechanism and are commonly combined in protocols.

Cognitive
Emerging

Selank

Russia's most studied anxiolytic peptide — reduces anxiety and enhances cognitive function without sedation or dependency.

250–500 mcg per dayView
Cognitive
Moderate

Semax

The most potent BDNF-upregulating peptide — acute cognitive enhancement, neuroprotection, and stroke recovery support.

200–900 mcg per day (intranasal); 50–300 mcg subcutaneousView
LongevityCognitive
Moderate

NMN

The NAD+ precursor taken daily by both Andrew Huberman and Bryan Johnson — restores cellular energy production that declines with age.

500 mg – 2 g/day, taken in the morningView

Supplements that pair with Noopept

These supplements directly amplify or support Noopept's mechanism of action.

CoreModerate

Lion's Mane

The only supplement clinically confirmed to stimulate NGF synthesis — directly promoting neurogenesis and cognitive resilience.

500–1000 mg daily (dual-extracted supplement); 1–3 g daily (whole food powder)View
SecondaryModerate

Bacopa Monnieri

Ayurvedic adaptogen with the strongest clinical evidence for memory consolidation and anxiety reduction of any herbal nootropic.

300 mg daily (standardised to 45% bacosides)View

Protocols using this peptide

Cognitiveadvanced

Cognitive Enhancement Protocol — Advanced

A comprehensive neuro-optimisation stack combining Semax, Noopept, and GH-axis optimisation for peak cognitive performance and neuroprotection.

Emerging evidenceTGA-approved compound

Cerebrolysin has 30+ years of clinical use across Europe and Asia for stroke recovery, with demonstrated BDNF-mimicking effects.

SemaxNoopeptIpamorelin + CJC-1295+1 more
6 steps8 weeks on, 4 weeks off — cycling required
$320–$480 AUD / monthView

Free tool

Protein targets for your Noopept

Protein requirements vary significantly by protocol goal and activity level.

80kg

144g

Daily total

48g

Per meal (3 meals)

1.8g/kg

Per kg bodyweight

Top sources to hit 144g daily

Chicken breast (cooked)~470g hits target
Whey protein (1 scoop ~30g)~180g hits target
Salmon fillet (cooked)~580g hits target
Eggs~21 eggs hits target
Greek yoghurt (200g serve)~8 serves hits target
Lean beef mince (cooked)~550g hits target

How this connects to your protocol

Amino acids are precursors to neurotransmitters including dopamine, serotonin, and acetylcholine. Adequate protein supports the cognitive benefits of your nootropic protocol.

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Targets are evidence-based estimates. Consult your practitioner for personalised advice.

Risks & side effects

May cause irritability or brain fog at higher doses
Headache reported — often addressed with choline supplementation
Legal grey area in Australia — classification varies
Limited long-term human safety data
Should not be combined with stimulants without medical supervision

How to access in Australia

Check with an AHPRA-registered practitioner for the current legal pathway to access this compound in Australia.

Find a prescriber

Australian clinics that prescribe Noopept or treat related goals.

Rx

Thrive Rx

Telehealth Clinic
4.8(312)

Australia's most thorough longevity and peptide clinic — blood panel first, protocol second.

$199–$599 AUD / month Australia-wide
AHPRA-registered clinicians
Comprehensive blood panel included in membership
Ongoing biomarker tracking every 6 months
Higher price point than GLP-1 only clinics
Requires full health assessment before any prescription
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Medical disclaimer

The information on this page is for educational purposes only and does not constitute medical advice. All peptide and supplement therapies should be discussed with an AHPRA-registered medical practitioner before use. ProtocolHub does not prescribe, dispense, or supply any therapeutic goods. Always consult a qualified healthcare professional before starting any new health protocol.

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